Description
PS-1145 is a potent and selective IκB kinase (IKK) inhibitor (IC₅₀ = 100 nM). Has no effect on PKA, PKC and CKII activity. PS-1145 efficiently inhibits both basal and induced NF-κB activity in PC cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line.
PS-1145 is a potent and selective IκB kinase (IKK) inhibitor (IC₅₀ = 100 nM). Has no effect on PKA, PKC and CKII activity. PS-1145 efficiently inhibits both basal and induced NF-κB activity in PC cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line.
Alternate Name/Synonyms: N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide
Appearance: Yellow solid
Formulation: N/A
CAS Number: 431898-65-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₁ClN₄O
Molecular Weight: 322.75
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective IκB kinase (IKK) inhibitor
MDL Number: MFCD08705411
PubChem CID: 9949093
SMILES: C1=CC(=CN=C1)C(=O)NC2=C3C(=CC(=C2)Cl)C4=C(N3)C=NC=C4
InChi: InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)
InChi Key: JZRMBDHPALEPDM-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |