PS48 | 1869

An allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site. It has recently been found that a combination of PS48, sodium butyrate (Cat. No. 1609-1000), a histone deacetylase inhibitor and the gene Oct-4, could enhance the reprogramming efficiency of keratinocytes isolated from human skin or hair follicles over 25-fold.

PS48 is an allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.

1869 | PS48 DataSheet

Alternate Name/Synonyms: (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acid

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1180676-32-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₅ClO₂

Molecular Weight: 286.75

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (100 mM) or EtOH (50 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An allosteric PDK1 activator

MDL Number: MFCD17215962

PubChem CID: 44141940

SMILES: C1=CC=C(C=C1)C(=CC(=O)O)CCC2=CC=C(C=C2)Cl

InChi: InChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-

InChi Key: LLJYFDRQFPQGNY-QINSGFPZSA-N