Description
An allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site. It has recently been found that a combination of PS48, sodium butyrate (Cat. No. 1609-1000), a histone deacetylase inhibitor and the gene Oct-4, could enhance the reprogramming efficiency of keratinocytes isolated from human skin or hair follicles over 25-fold.
PS48 is an allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.
Alternate Name/Synonyms: (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acid
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1180676-32-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₅ClO₂
Molecular Weight: 286.75
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: DMSO (100 mM) or EtOH (50 mM)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An allosteric PDK1 activator
MDL Number: MFCD17215962
PubChem CID: 44141940
SMILES: C1=CC=C(C=C1)C(=CC(=O)O)CCC2=CC=C(C=C2)Cl
InChi: InChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
InChi Key: LLJYFDRQFPQGNY-QINSGFPZSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |