PTEN Antibody| F42884-0.08ML/F42884-0.4ML/R20282-0.1ML/R32154/V3923-20UG

PTEN Antibody| F42884-0.08ML/F42884-0.4ML/R20282-0.1ML/R32154/V3923-20UG | Gentaur UK, US & Europe Distribution

Background: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Xenopus

Application: WB, IF, IHC, ELISA

Application Details: Western blot: 1:1000, Immunofluorescence: 1:10-1:50, IHC (Paraffin): 1:10-1:50

Application Note: Titration of the PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This PTEN antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 306-335 from the human protein was used as the immunogen for this PTEN antibody.

Storage: Aliquot the PTEN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A