Purified Anti-Mouse CD366/Tim-3 Monoclonal Antibody | DL22113F

Purified Anti-Mouse CD366/Tim-3 Monoclonal Antibody | DL22113F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: TIM3, TIMD3, HAVcr-2, TIMD-3

Reactivity: Mouse

Application: FCM

Background: CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells) . Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

Concentration: 0.2 mg/mL

Conjugation: Unconjugated

Buffer: PBS with 0.05% Proclin300

Clone: RMT3-23

Isotype: Rat IgG2a, κ