PX-866 | 1965

Cell-permeable. A derivative of Wortmannin (Cat. No. 1670-1), that potently and irreversibly inhibits PI 3-kinase with selectivity for p110⍺ (IC₅₀ = 0.1 nM). Displays antitumor activity.

PX-866 is a derivative of Wortmannin (Cat. No. 1670-1), that potently and irreversibly inhibits PI 3-kinase with selectivity for p110⍺ (IC₅₀ = 0.1 nM). Displays antitumor activity.

1965 | PX-866 DataSheet

Alternate Name/Synonyms: DJM-166; DJM-2-166

Appearance: Orange solid

Formulation: N/A

CAS Number: 502632-66-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₃₅NO₈

Molecular Weight: 525.59

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~ 25 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A potent PI3 Kinase inhibitor

MDL Number: MFCD07784511

PubChem CID: 9849735

SMILES: CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C(=CN(CC=C)CC=C)C4=C(C3=O)O)COC)C)C

InChi: InChI=1S/C29H35NO8/c1-7-11-30(12-8-2)14-17-23-26(34)25(33)22-18-9-10-20 (32)28(18,4)13-19(37-16(3)31)24(22)29(23,5)21(15-36-6)38-27(17)35/h7-8, 14,18-19,21,34H,1-2,9-13,15H2,3-6H3/b17-14+/t18-,19+,21+,28-,29-/m0/s1

InChi Key: QIUASFSNWYMDFS-NILGECQDSA-N