REST Antibody| F45229-0.08ML/F45229-0.4ML/R35002-100UG

REST Antibody| F45229-0.08ML/F45229-0.4ML/R35002-100UG | Gentaur UK, US & Europe Distribution

Background: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the REST antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This REST antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 542-570 from the human protein was used as the immunogen for this REST antibody.

Storage: Aliquot the REST antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A