RG 108 | 1679

A DNA methyltransferase (DNMT) inhibitor. RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In combination with BIX 01294 (Cat. No. 1678-5), RG 108 enhances reprogramming.

RG 108 is a DNA methyltransferase (DNMT) inhibitor. RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences.

1679 | RG 108 DataSheet

Alternate Name/Synonyms: N-Phthalyl-L-tryptophan

Appearance: Beige to yelllow solid

Formulation: N/A

CAS Number: 48208-26-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₄N₂O₄

Molecular Weight: 334.33

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A DNA methyltransferase (DNMT) inhibitor

MDL Number: N/A

PubChem CID: 702558

SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)C(CC3=CNC4=CC=CC=C43)C(=O)O

InChi: InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)/t16-/m0/s1

InChi Key: HPTXLHAHLXOAKV-INIZCTEOSA-N