RIPA-56 | B3051

RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with an IC₅₀ of 13 nM. It protects HT-29 cells against TNFα-induced necroptosis with an EC₅₀ of 28 nM. RIPA-56 efficiently reduces TNFα-induced mortality and multiorgan damage in a systemic inflammatory response syndrome (SIRS) mice model. Modulators of RIP kinase 1 may be beneficial against SARS-CoV-2 based on interaction of RIP kinase 1 with SARS-CoV-2 protein Nsp12.

RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with an IC₅₀ of 13 nM. It protects HT-29 cells against TNFα-induced necroptosis with an EC₅₀ of 28 nM. RIPA-56 efficiently reduces TNFα-induced mortality and multiorgan damage in a systemic inflammatory response syndrome (SIRS) mice model. Modulators of RIP kinase 1 may be beneficial against SARS-CoV-2 based on interaction of RIP kinase 1 with SARS-CoV-2 protein Nsp12.

B3051 | RIPA-56 DataSheet

Alternate Name/Synonyms: N-benzyl-N-hydroxy-2,2-dimethylbutanamide

Appearance: White to beige powder

Formulation:

CAS Number: 1956370-21-0

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₃H₁₉NO₂

Molecular Weight: 221.29

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~2 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A highly potent and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase

MDL Number: MFCD30738006

PubChem CID: 121439991

SMILES: CCC(C)(C)C(=O)N(CC1=CC=CC=C1)O

InChi: InChI=1S/C13H19NO2/c1-4-13(2,3)12(15)14(16)10-11-8-6-5-7-9-11/h5-9,16H,4,10H2,1-3H3

InChi Key: AVYVHIKSFXVDBG-UHFFFAOYSA-N