ROBO1 polyclonal Antibody | BS60781

ROBO1 polyclonal Antibody | BS60781 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Specialized cells at the midline, which separates the left and right halves of the CNS, have a number of roles in directing growth cone behavior . In the vertebrate spinal cord, the insect ventral nerve cord and in C. elegans, midline cells produce guidance cues such as nectins and slit, which act as attractants and repellents, respectively . These cells may act as gatekeepers to prevent axons from crossing the midline and to induce a switch in growth cone responsiveness to guidance cues beyond the gateway . One such gatekeeper, Robo, is an axon guidance receptor that defines a novel subfamily of Ig superfamily proteins that are conserved from fruit flies to mammals . Robo acts as a receptor for the repellent Slit and functions in a cell-autonomous fashion . Non-crossing axons express high levels of Robo, whereas crossing axons express low levels of Robo before reaching the midline and high levels after they cross . Robo1 and Robo2 are two human homologs of the Drosophila protein Roundabout . Robo1 is also homologous to the C. elegans gene sax3, whereas Robo2 is homologous to the zebrafish gene astray .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ROBO1 polyclonal Antibody detects endogenous levels of ROBO1 protein.

Molecular Weight: ~ 181 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Roundabout homolog 1; Deleted in U twenty twenty; H-Robo-1; ROBO1; DUTT1

Immunogen: A synthetic peptide corresponding to residues in Human ROBO1

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: