BW
ROBO1 polyclonal Antibody | BS60781
- SKU:
- BW-BS60781
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- Usually ships in 5 working days
Description
ROBO1 polyclonal Antibody | BS60781 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: Specialized cells at the midline, which separates the left and right halves of the CNS, have a number of roles in directing growth cone behavior . In the vertebrate spinal cord, the insect ventral nerve cord and in C. elegans, midline cells produce guidance cues such as nectins and slit, which act as attractants and repellents, respectively . These cells may act as gatekeepers to prevent axons from crossing the midline and to induce a switch in growth cone responsiveness to guidance cues beyond the gateway . One such gatekeeper, Robo, is an axon guidance receptor that defines a novel subfamily of Ig superfamily proteins that are conserved from fruit flies to mammals . Robo acts as a receptor for the repellent Slit and functions in a cell-autonomous fashion . Non-crossing axons express high levels of Robo, whereas crossing axons express low levels of Robo before reaching the midline and high levels after they cross . Robo1 and Robo2 are two human homologs of the Drosophila protein Roundabout . Robo1 is also homologous to the C. elegans gene sax3, whereas Robo2 is homologous to the zebrafish gene astray .
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ROBO1 polyclonal Antibody detects endogenous levels of ROBO1 protein.
Molecular Weight: ~ 181 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Roundabout homolog 1; Deleted in U twenty twenty; H-Robo-1; ROBO1; DUTT1
Immunogen: A synthetic peptide corresponding to residues in Human ROBO1
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: