SCG3 Antibody (C-term) [AMR09825G]

SCG3 Antibody (C-term) [AMR09825G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SCG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-406 amino acids from the C-terminal region of human SCG3.

Cellular Localisation: Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P47868}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P47868}; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts. {ECO:0000250|UniProtKB:P47868}

Molecular Weight: 53005

Clone: Polyclonal

Gene Name: SCG3

Gene ID: 29106

Function: Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184) . Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity) . May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827) .

Summary: Tissue Location: Expressed in brain, heart, kidney, liver and skeletal muscle.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Secretogranin-3, Secretogranin III, SgIII, SCG3