SFXN1 Antibody (C-term) [AMR09894G]

SFXN1 Antibody (C-term) [AMR09894G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SFXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human SFXN1.

Cellular Localisation: Mitochondrion inner membrane; Multi-pass membrane protein

Molecular Weight: 35619

Clone: Polyclonal

Gene Name: SFXN1 (HGNC:16085)

Gene ID: 94081

Function: Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778) . Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778) . Transports both D-serine and L-serine (PubMed:30442778) . Also able to transport other amino-acids, such as alanine (PubMed:30442778) . May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity) .

Summary: Tissue Location: Highly expressed in tissues with high one-carbon metabolism activity, such as blood, liver and kidney

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Sideroflexin-1, Tricarboxylate carrier protein, TCC, SFXN1