SGF29 Antibody (C-term) [APR32132G]

SGF29 Antibody (C-term) [APR32132G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SGF29 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-208 amino acids from the C-terminal region of human SGF29.

Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:P0C606}.

Molecular Weight: 33238

Clone: Polyclonal

Gene Name: SGF29 (HGNC:25156)

Gene ID: 112869

Function: Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293) . SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293) . In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016) . Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: SAGA-associated factor 29 homolog, Coiled-coil domain-containing protein 101, CCDC101, SGF29