SIRT2 Inhibitor, AGK2 | 1651

A potent inhibitor of sirtuin 2 (SIRT2) (IC₅₀ = 3.5 µM). AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson’s disease.

SIRT2 Inhibitor, AGK2 is a potent inhibitor of sirtuin 2 (SIRT2) (IC₅₀ = 3.5 µM). AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson’s disease.

1651 | SIRT2 Inhibitor, AGK2 DataSheet

Alternate Name/Synonyms: AGK2, (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide

Appearance: Yellow solid

Formulation: N/A

CAS Number: 304896-28-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₁₃Cl₂N₃O₂

Molecular Weight: 434.27

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A SIRT2 inhibitor

MDL Number: MFCD01909444

PubChem CID: 2130404

SMILES: C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N

InChi: InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14 (13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+

InChi Key: SVENPFFEMUOOGK-SDNWHVSQSA-N