SIRT2 Inhibitor, B2 | 2085

Cell-permeable. A Sirtuin 2 (SIRT2) inhibitor (IC50 = 35 µM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.

SIRT2 Inhibitor, is a Sirtuin 2 (SIRT2) inhibitor (IC50 = 35 µM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.

2085 | SIRT2 Inhibitor, B2 DataSheet

Alternate Name/Synonyms: 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline, CPNQ

Appearance: Yellow solid

Formulation: N/A

CAS Number: 115687-05-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₀H₁₇ClN₄O₃

Molecular Weight: 396.83

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent SIRT2 inhibitor

MDL Number: MFCD02039810

PubChem CID: 3953303

SMILES: C1CN(CCN1C2=C3C=CC=NC3=C(C=C2)[N+](=O)[O-])C(=O)C4=CC=C(C=C4)Cl

InChi: InChI=1S/C20H17ClN4O3/c21-15-5-3-14(4-6-15)20(26)24-12-10-23(11-13-24) 17-7-8-18(25(27)28)19-16(17)2-1-9-22-19/h1-9H,10-13H2

InChi Key: KLNPVNZJCWIQSK-UHFFFAOYSA-N