SIRT6 Antibody| F43446-0.08ML/F43446-0.4ML/F54008-0.1ML/R31770

SIRT6 Antibody| F43446-0.08ML/F43446-0.4ML/F54008-0.1ML/R31770 | Gentaur UK, US & Europe Distribution

Background: NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein (By similarity).

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:10-1:50

Application Note: Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This SIRT6 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 276-305 from the human protein was used as the immunogen for this SIRT6 antibody.

Storage: Aliquot the SIRT6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A