SKPin C1 | 2343

Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.

SKPin C1 inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding.

2343 | SKPin C1 DataSheet

Alternate Name/Synonyms: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinyl­methyl)-2-thioxo-5-thiazolidinylidene]methyl]pheno­xy]acetic acid

Appearance: Yellow solid

Formulation: N/A

CAS Number: 432001-69-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₃BrN₂O₄S₂

Molecular Weight: 465.34

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An ubiquitin E3 ligase inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: BrC1=CC(/C=C2SC(N(CC3=CN=CC=C3)C\2=O)=S)=C(OCC(O)=O)C=C1

InChi: InChI=1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7-

InChi Key: IYCJJVVXEHZJHE-CHHVJCJISA-N