Description
Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.
SKPin C1 inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding.
Alternate Name/Synonyms: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
Appearance: Yellow solid
Formulation: N/A
CAS Number: 432001-69-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₃BrN₂O₄S₂
Molecular Weight: 465.34
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (15 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An ubiquitin E3 ligase inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: BrC1=CC(/C=C2SC(N(CC3=CN=CC=C3)C\2=O)=S)=C(OCC(O)=O)C=C1
InChi: InChI=1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7-
InChi Key: IYCJJVVXEHZJHE-CHHVJCJISA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |