SNS-032 | 9490

SNS-032 is a potent CDK inhibitor. Inhibits cyclin-dependent kinases (cdks) 9, 2 and 7 with IC₅₀ values of 4, 38 and 62 nM respectively. Displays no activity against 190 additional kinases (IC₅₀ >1000 nM). Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.

SNS-032 is a potent CDK inhibitor. Inhibits cyclin-dependent kinases (cdks) 9, 2 and 7 with IC₅₀ values of 4, 38 and 62 nM respectively. Displays no activity against 190 additional kinases (IC₅₀ >1000 nM). Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.

9490 | SNS-032 DataSheet

Alternate Name/Synonyms: N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide; BMS-387032

Appearance: White solid

Formulation: N/A

CAS Number: 345627-80-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₇H₂₄N₄O₂S₂

Molecular Weight: 380.53

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent CDK (cyclin-dependent kinase) inhibitor

MDL Number: N/A

PubChem CID: 3025986

SMILES: CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3

InChi: InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)

InChi Key: OUSFTKFNBAZUKL-UHFFFAOYSA-N