Sphingosine Kinase Inhibitor, SKI-II | 2047

Cell-permeable. SKI-II is selective a non-lipid sphingosine kinase (SK) inhibitor. It displays non-ATP-competitive inhibition of human recombinant GST-SK 1 with an IC50 value of 0.5 µM, with no inhibition against ERK2, PI3-kinase, or PKCα at concentrations up to 60 µM.

Sphingosine Kinase Inhibitor, SKI-II is selective a non-lipid sphingosine kinase (SK) inhibitor. It displays non-ATP-competitive inhibition of human recombinant GST-SK 1 with an IC50 value of 0.5 µM, with no inhibition against ERK2, PI3-kinase, or PKCα at concentrations up to 60 µM.

2047 | Sphingosine Kinase Inhibitor, SKI-II DataSheet

Alternate Name/Synonyms: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol

Appearance: Off-white solid

Formulation: N/A

CAS Number: 312636-16-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₁ClN₂OS

Molecular Weight: 302.78

Cell-Permeable?: Yes

Purity: ≥90% by NMR

Solubilities: DMSO (100 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A non-lipid pan-sphingosine kinase (SK) inhibitor

MDL Number: MFCD00733553

PubChem CID: 753704

SMILES: C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl

InChi: InChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13 (19)8-6-12/h1-9,19H,(H,17,18)

InChi Key: ZFGXZJKLOFCECI-UHFFFAOYSA-N