SPRR3 polyclonal Antibody | BS71686

SPRR3 polyclonal Antibody | BS71686 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Mouse,Rat

Application: WB,IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: Esophagin, also known as small proline rich protein 3 (SPR3) or cornifin β, belongs to the cornifin family of cornified-envelope structural proteins. It is expressed in mucosal epithelia such as esophagus and tongue and is strongly induced during epidermal keratinocyte differentiation. Due to its highly inducible nature, Esophagin is considered a marker of squamous differentiation. Esophagin serves as a cross-linking protein within the cornified cell envelope and may play a role in the maintenance of normal esophageal epithelial homeostasis. It shares significant homology with the related proteins, SPRR1 and SPRR2. Esophagin is typically not expressed in healthy human epithelium, but its expression is upregulated in numerous hyperproliferative disorders of the skin. In contrast, its expression is dramatically downregulated in esophageal squamous cell carcinoma

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SPRR3 polyclonal Antibody detects endogenous levels of SPRR3 protein.

Molecular Weight: ~ 26 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Small proline-rich protein 3; 22 kDa pancornulin; Cornifin beta; Esophagin; SPRR3; SPRC

Immunogen: Recombinant protein of human SPRR3

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: