BW
SPRR3 polyclonal Antibody | BS71686
- SKU:
- BW-BS71686
- Availability:
- Usually ships in 5 working days
Description
SPRR3 polyclonal Antibody | BS71686 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Mouse,Rat
Application: WB,IF
Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200
Background: Esophagin, also known as small proline rich protein 3 (SPR3) or cornifin β, belongs to the cornifin family of cornified-envelope structural proteins. It is expressed in mucosal epithelia such as esophagus and tongue and is strongly induced during epidermal keratinocyte differentiation. Due to its highly inducible nature, Esophagin is considered a marker of squamous differentiation. Esophagin serves as a cross-linking protein within the cornified cell envelope and may play a role in the maintenance of normal esophageal epithelial homeostasis. It shares significant homology with the related proteins, SPRR1 and SPRR2. Esophagin is typically not expressed in healthy human epithelium, but its expression is upregulated in numerous hyperproliferative disorders of the skin. In contrast, its expression is dramatically downregulated in esophageal squamous cell carcinoma
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: SPRR3 polyclonal Antibody detects endogenous levels of SPRR3 protein.
Molecular Weight: ~ 26 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Small proline-rich protein 3; 22 kDa pancornulin; Cornifin beta; Esophagin; SPRR3; SPRC
Immunogen: Recombinant protein of human SPRR3
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: