STAT3 Antibody| F46167-0.08ML/F47582-0.4ML/R32089/V3921-20UG

STAT3 Antibody| F46167-0.08ML/F47582-0.4ML/R32089/V3921-20UG | Gentaur UK, US & Europe Distribution

Background: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: IF, WB, ELISA

Application Details: Western blot: 1:1000, Immunofluorescence: 1:200

Application Note: Titration of the STAT-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This STAT-3 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 711-743 from the human protein was used as the immunogen for this STAT-3 antibody.

Storage: Aliquot the STAT-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A