STRAP polyclonal Antibody | BS70705

STRAP polyclonal Antibody | BS70705 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB,IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: STRAP, another antagonist to the TGFβ signalling pathway, specifically interacts with Smad7, but not Smad6, to synergistically block TGF∫-induced transcriptional activation. The gene encoding the human homolog of STRAP (as designated in mouse), called unr-interacting protein, maps to chromosome 12p12.3. Unr-interacting protein is 97% homologous to STRAP at the amino acid level. The unr-interacting protein binds unr, a cytoplasmic RNA-binding protein with five cold-shock domains that is involved in RNA translation. The presence of the STRAP gene in a variety of species from mammals to yeast, indicates that STRAP function is evolutionarily conserved in eukaryotic cells.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: STRAP polyclonal Antibody detects endogenous levels of STRAP protein.

Molecular Weight: ~ 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MAWD; PT-WD; UNRIP;

Immunogen: Recombinant protein of human STRAP.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: