Sulfo-SMCC | 2320

KEY FEATURES: • Amine reactive Sulfo-NHS ester that crosslinks efficiently with primary amine-containing molecules • Has a maleimide functional group that can be utilized to react specifically with cysteines or sulfhydryl (-SH) groups • Water-soluble; can be used under physiologic conditions • Has a spacer arm length of 8.3 Å (9 atom) • Unlike other maleimide-activated antibodies, those made with Sulfo-SMCC crosslinkers are often more stable, due to the inductive stabilizing effects of the cyclohexyl ring moeity APPLICATIONS: • Routinely used to prepare hapten-carrier protein and antibody-enzyme conjugates, such as HRP conjugation. • Wide range of uses for both small molecule reactions and large biomolecule applications.

Sulfo-SMCC is a water-soluble heterobifunctional protein crosslinker.

2320 | Sulfo-SMCC DataSheet

Alternate Name/Synonyms: 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 92921-24-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₇N₂NaO₉S

Molecular Weight: 436.37

Cell-Permeable?: No

Purity: ≥90% by NMR

Solubilities: H₂O (>10 mg/ml)

Handling: Protect from moisture

Country of Origin: USA

Tag Line: A water-soluble heterobifunctional protein crosslinker

MDL Number: MFCD00054978

PubChem CID: 4618794

SMILES: C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)ON3C(=O)CC(C3=O)S(=O)(=O)[O-].[Na+]

InChi: InChI=1S/C16H18N2O9S.Na/c19-12-5-6-13(20)17(12)8-9-1-3-10(4-2-9)16(23)27-18-14(21)7-11(15(18)22)28(24,25)26;/h5-6,9-11H,1-4,7-8H2,(H,24,25,26);/q;+1/p-1

InChi Key: VUFNRPJNRFOTGK-UHFFFAOYSA-M