SUMO2/3 Antibody| F42018-0.08ML/F42018-0.4ML/RQ6517/V2257-20UG/V2257IHC-7ML

SUMO2/3 Antibody| F42018-0.08ML/F42018-0.4ML/RQ6517/V2257-20UG/V2257IHC-7ML | Gentaur UK, US & Europe Distribution

Background: SUMO2 and SUMO3 are members of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Rat, Bovine, Pig, Primate, Chicken, Zebrafish, Hamster, Xenopus

Application: IHC, IF, WB, ELISA

Application Details: Western blot: 1:1000, Immunofluorescence: 1:10-1:50, IHC (Paraffin): 1:10-1:50

Application Note: Titration of the SUMO2/3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This SUMO2/3 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 53-84 from human SUMO3 was used as the immunogen for this SUMO2/3 antibody.

Storage: Aliquot the SUMO2/3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A