SUV39H2 Antibody (KMT1B)| F42487-0.08ML/F42487-0.4ML

SUV39H2 Antibody (KMT1B)| F42487-0.08ML/F42487-0.4ML | Gentaur UK, US & Europe Distribution

Background: The murine gene Suv39h2/kmt1b encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: N/A

Application: WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100

Application Note: Titration of the SUV39H2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This SUV39H2 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 93-122 from the human protein was used as the immunogen for this KMT1B / SUV39H2 antibody.

Storage: Aliquot the SUV39H2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A