Tenalisib | B2439

Tenalisib is a potent, and selective PI3Kδ and PI3Kγ inhibitor with IC₅₀ values of 25 and 33 nM, respectively. Displays good selectivity over p110α (>300-fold) and p110β (>100-fold) isoforms.

Tenalisib is a potent, and selective PI3Kδ and PI3Kγ inhibitor with IC₅₀ values of 25 and 33 nM, respectively. Displays good selectivity over p110α (>300-fold) and p110β (>100-fold) isoforms.

B2439 | Tenalisib DataSheet

Alternate Name/Synonyms: 3-(3-fluorophenyl)-2-[(1S)-1-(7H-purin-6-ylamino)propyl]chromen-4-one, RP6530

Appearance: Crystalline solid

Formulation:

CAS Number: 1639417-53-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₁₈FN₅O₂

Molecular Weight: 415.43

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective p110δ/γ PI3K dual inhibitor

MDL Number:

PubChem CID: 86291103

SMILES: CCC(C1=C(C(=O)C2=CC=CC=C2O1)C3=CC(=CC=C3)F)NC4=NC=NC5=C4NC=N5

InChi: InChI=1S/C23H18FN5O2/c1-2-16(29-23-19-22(26-11-25-19)27-12-28-23)21-18(13-6-5-7-14(24)10-13)20(30)15-8-3-4-9-17(15)31-21/h3-12,16H,2H2,1H3,(H2,25,26,27,28,29)/t16-/m0/s1

InChi Key: HDXDQPRPFRKGKZ-INIZCTEOSA-N