Description
Tenalisib is a potent, and selective PI3Kδ and PI3Kγ inhibitor with IC₅₀ values of 25 and 33 nM, respectively. Displays good selectivity over p110α (>300-fold) and p110β (>100-fold) isoforms.
Tenalisib is a potent, and selective PI3Kδ and PI3Kγ inhibitor with IC₅₀ values of 25 and 33 nM, respectively. Displays good selectivity over p110α (>300-fold) and p110β (>100-fold) isoforms.
Alternate Name/Synonyms: 3-(3-fluorophenyl)-2-[(1S)-1-(7H-purin-6-ylamino)propyl]chromen-4-one, RP6530
Appearance: Crystalline solid
Formulation:
CAS Number: 1639417-53-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₁₈FN₅O₂
Molecular Weight: 415.43
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >50 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent and selective p110δ/γ PI3K dual inhibitor
MDL Number:
PubChem CID: 86291103
SMILES: CCC(C1=C(C(=O)C2=CC=CC=C2O1)C3=CC(=CC=C3)F)NC4=NC=NC5=C4NC=N5
InChi: InChI=1S/C23H18FN5O2/c1-2-16(29-23-19-22(26-11-25-19)27-12-28-23)21-18(13-6-5-7-14(24)10-13)20(30)15-8-3-4-9-17(15)31-21/h3-12,16H,2H2,1H3,(H2,25,26,27,28,29)/t16-/m0/s1
InChi Key: HDXDQPRPFRKGKZ-INIZCTEOSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |