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thymidine phosphorylase Polyclonal Antibody | BS65869
- SKU:
- BW-BS65869
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- Usually ships in 5 working days
Description
thymidine phosphorylase Polyclonal Antibody | BS65869 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,
Application: IHC-P,
Application Range: IHC-P=1:100-500
Background: In the presence of inorganic orthophosphate, the platelet-derived endothelial growth factor (PD-ECGF) thymidine phosphorylase (TP) (gliostatin) catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.
Storage & Stability: Store at 4°C short term. Aliquot and store at -42°C long term. Avoid freeze-thaw cycles.
Specificity: thymidine phosphorylase Polyclonal Antibody detects endogenous levels of thymidine phosphorylase protein.
Molecular Weight: ~50kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: ECGF 1; PDEGF; ECGF1; Endothelial cell growth factor 1; Endothelial cell growth factor 1 platelet derived; Gliostatin; hPD ECGF; MNGIE; PD ECGF; PDECGF; PDEGF; Platelet derived endothelial growth factor; TdRPase; TP; TYMP; Thymidine Phosphorylase; TYPH_HUMAN; TdRPase.
Immunogen: KLH conjugated synthetic peptide derived from human Thymidine Phosphorylase:121-220/482
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: affinity purified by Protein A
Pathway: