thymidine phosphorylase Polyclonal Antibody | BS65869

thymidine phosphorylase Polyclonal Antibody | BS65869 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,

Application: IHC-P,

Application Range: IHC-P=1:100-500

Background: In the presence of inorganic orthophosphate, the platelet-derived endothelial growth factor (PD-ECGF) thymidine phosphorylase (TP) (gliostatin) catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.

Storage & Stability: Store at 4°C short term. Aliquot and store at -42°C long term. Avoid freeze-thaw cycles.

Specificity: thymidine phosphorylase Polyclonal Antibody detects endogenous levels of thymidine phosphorylase protein.

Molecular Weight: ~50kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ECGF 1; PDEGF; ECGF1; Endothelial cell growth factor 1; Endothelial cell growth factor 1 platelet derived; Gliostatin; hPD ECGF; MNGIE; PD ECGF; PDECGF; PDEGF; Platelet derived endothelial growth factor; TdRPase; TP; TYMP; Thymidine Phosphorylase; TYPH_HUMAN; TdRPase.

Immunogen: KLH conjugated synthetic peptide derived from human Thymidine Phosphorylase:121-220/482

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: affinity purified by Protein A

Pathway: