TLR1 Polyclonal Antibody | E-AB-40137

TLR1 Polyclonal Antibody | E-AB-40137 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: CD281, CD281 antigen, KIAA0012, LPRS5, rsc786, TIL, TIL. LPRS5, Tlr1, TLR1, Toll (Drosophila) homolog, Toll like receptor 1, Toll-like receptor 1, Toll/interleukin-1 receptor-like protein

Application: IHC

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Immunology, Signaling transduction

Background: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Concentration: 2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant human TLR1 protein

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: IHC 1:50-1:100

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A