Description
TLR1 Polyclonal Antibody | E-AB-40137 | Gentaur UK, US & Europe Distribution
Type: Polyclonal Antibody
Synonyms: CD281, CD281 antigen, KIAA0012, LPRS5, rsc786, TIL, TIL. LPRS5, Tlr1, TLR1, Toll (Drosophila) homolog, Toll like receptor 1, Toll-like receptor 1, Toll/interleukin-1 receptor-like protein
Application: IHC
Reactivity: Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Immunology, Signaling transduction
Background: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Concentration: 2 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant human TLR1 protein
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification Method: Affinity purification
Dilution: IHC 1:50-1:100
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): N/A
Molecular Weight(Observed): N/A