TNFR1 Antibody| F41241-0.08ML/F41241-0.4ML/R30310

TNFR1 Antibody| F41241-0.08ML/F41241-0.4ML/R30310 | Gentaur UK, US & Europe Distribution

Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, FACS, ELISA

Application Details: Western blot: 1:1000, Flow Cytometry: 1:10-1:50

Application Note: Titration of the TNFR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This TNFR1 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 252-281 from the human protein was used as the immunogen for this TNFR1 antibody.

Storage: Aliquot the TNFR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A