Description
TOFA is an allosteric inhibitor of acetyl Co-A carboxylase (ACC1). TOFA blocks fatty acid synthesis and Induces apoptosis in a dose-dependent manner. Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells. TOFA impairs glucose-stimulated insulin secretion after chronic treatment.
TOFA is an allosteric inhibitor of acetyl Co-A carboxylase (ACC1). TOFA blocks fatty acid synthesis and Induces apoptosis in a dose-dependent manner. Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells. TOFA impairs glucose-stimulated insulin secretion after chronic treatment.
Alternate Name/Synonyms: 5-(tetradecyloxy)-2-furancarboxylic acid; RM14514
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 54857-86-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₃₂O₄
Molecular Weight: 324.5
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (~2 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An allosteric acetyl Co-A carboxylase (ACC1) inhibitor
MDL Number: NFCD01726059
PubChem CID: 115175
SMILES: CCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)O
InChi: InChI=1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
InChi Key: CZRCFAOMWRAFIC-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |