Description
Topiramate is a potent antiepileptic drug with a broad spectrum of activity. Topiramate acts as an antagonist of GluK1 kainate receptors (IC50 = 0.46 μM); also acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 μM) and inhibits L-type Ca2+ channels. Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.
Topiramate is a potent antiepileptic drug with a broad spectrum of activity. Topiramate acts as an antagonist of GluK1 kainate receptors (IC50 = 0.46 μM); also acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 μM) and inhibits L-type Ca2+ channels. Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.
Alternate Name/Synonyms: 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
Appearance: White solid
Formulation:
CAS Number: 97240-79-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₂H₂₁NO₈S
Molecular Weight: 339.36
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities:
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An anticonvulsant and an antagonist of GluK1 kainate receptors
MDL Number: MFCD00865320
PubChem CID: 5284627
SMILES: CC(O2)(C)O[C@H]1[C@@H]2[C@H](OC(C)(C)O3)[C@@]3(COS(N)(=O)=O)OC1
InChi: InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
InChi Key: KJADKKWYZYXHBB-XBWDGYHZSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |