Description
Trabectedin is a natural product originally isolated from the sea squirt, Ecteinascidia turbinata and is currently prepared synthetically. It interferes with transcription factors, DNA‐binding proteins, DNA repair pathways and shows potent antitumor activity. It suppresses the proliferation of Clear cell sarcoma cell lines with IC₅₀ values ranging from 0.30 nM-0.50 nM. It is approved for the treatment of unresectable or metastatic liposarcoma or leiomyosarcoma who received prior chemotherapy with an anthracycline.
Trabectedin is a natural product originally isolated from the sea squirt, Ecteinascidia turbinata and is currently prepared synthetically. It interferes with transcription factors, DNA‐binding proteins, DNA repair pathways and shows potent antitumor activity. It suppresses the proliferation of Clear cell sarcoma cell lines with IC₅₀ values ranging from 0.30 nM-0.50 nM. It is approved for the treatment of unresectable or metastatic liposarcoma or leiomyosarcoma who received prior chemotherapy with an anthracycline.
Alternate Name/Synonyms: Ecteinascidin; [(1R,2R,3R,11S,12S,14R,26R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-3,4-dihydro-2H-isoquinoline]-22-yl] acetate; ecteinascidin 743; ET-743
Appearance: White to off-white powder
Formulation:
CAS Number: 114899-77-3
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₃₉H₄₃N₃O₁₁S
Molecular Weight: 761.84
Cell-Permeable?: TRUE
Purity: ≥ 98%
Solubilities: Soluble in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An antitumor agent
MDL Number: MFCD00874849
PubChem CID: 108150
SMILES: CC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)O)COC(=O)C8(CS5)C9=CC(=C(C=C9CCN8)O)OC)OCO7)C)OC(=O)C)C(=C1OC)O
InChi: InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1
InChi Key: PKVRCIRHQMSYJX-AIFWHQITSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |