TRAF2 Antibody| F40259-0.08ML/F40259-0.4ML/R31114

TRAF2 Antibody| F40259-0.08ML/F40259-0.4ML/R31114 | Gentaur UK, US & Europe Distribution

Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Format: Purified

Clone: 214CT16.3.4

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Isotype: Mouse IgG1, k

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: IF, WB, ELISA

Application Details: Immunofluorescence: 1:10-1:50, Western blot: 1:100-1:1000

Application Note: Titration of the TRAF2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This TRAF2 antibody is available for research use only.

Purity: Purified

Immunogen: This TRAF2 antibody was produced from a mouse immunized with TRAF2 recombinant protein.

Storage: Aliquot the TRAF2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A