Description
TREM2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
7357 | TREM2 human recombinant DataSheet
Biomolecule/Target: TREM2
Synonyms: Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c
Alternates names: Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c
Taglines: Involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines
NCBI Gene ID #: 10850
NCBI Gene Symbol: CCL27
Gene Source: Human
Accession #: Q9Y4X3
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 20.4 kDa (181 aa, 19-161 aa + His Tag), confirmed by MALDI-TOF.
Concentration: 0.25 mg/ml
Appearance: Liquid
Physical form description: 0.25 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 10% glycerol.
Reconstitution Instructions: N/A
Amino acid sequence: MFLLPPSTAC CTQLYRKPLS DKLLRKVIQV ELQEADGDCH LQAFVLHLAQ RSICIHPQNP SLSQWFEHQE RKLHGTLPKL NFGMLRKMG.