Tyrphostin AG 490 | 1570

Selectively inhibits EGF receptor auto-phosphorylation (IC₅₀ = 100 µM) and selectively inhibits DNA synthesis and cell growth; induces apoptosis. A JAK2 inhibitor. Blocks growth of leukemia cells in vivo and in vitro.

Tyrphostin AG490 is a selective inhibitor of EGF receptor auto-phosphorylation (IC₅₀ = 100 µM).

1570 | Tyrphostin AG 490 DataSheet

Alternate Name/Synonyms: 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide, AG 490

Appearance: Off-white solid

Formulation: N/A

CAS Number: 133550-30-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₄N₂O₃

Molecular Weight: 294.31

Cell-Permeable?: Yes

Purity: ≥99%

Solubilities: DMSO (100 mM) and ETOH (20 mM)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: An EGFR inhibitor

MDL Number: MFCD00236452

PubChem CID: 5328779

SMILES: C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N

InChi: InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+

InChi Key: TUCIOBMMDDOEMM-RIYZIHGNSA-N