UIMC1 polyclonal Antibody | BS8795

UIMC1 polyclonal Antibody | BS8795 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IF

Application Range: WB: 1:500~1:2000 IF: 1:50~1:200

Background: Receptor-associated protein 80 (RAP80), also known as Ubiquitin interaction motif-containing protein 1 (UIMC1) or Retinoid X receptor-interacting protein 110 (RXRIP110), is a 719 amino acid protein. Acting as a transcription repressor, RAP80 interacts with GCNF, thereby blocking GCNF interaction with the corepressor N-CoR. Localized to the nucleus, RAP80 is phosphorylated upon DNA damage. RAP80 contains two nuclear localization signals and one UIM (ubiquitin-interacting motif) repeat in the N-terminus, while the C-terminus contains two zinc fingers, a third nuclear localization signal and a potential PEST sequence. RAP80 is expressed as four isoforms produced by alternative splicing and is present in thymus, testis, heart and ovary.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: UIMC1 polyclonal Antibody detects endogenous levels of UIMC1 protein.

Molecular Weight: ~ 60, 80, 120kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1; UIMC1; RAP80, RXRIP110

Immunogen: Recombinant full length Human UIMC1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: ATP-Dependent Chromatin Remodeling Complexes,