Description
UIMC1 polyclonal Antibody | BS8795 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IF
Application Range: WB: 1:500~1:2000 IF: 1:50~1:200
Background: Receptor-associated protein 80 (RAP80), also known as Ubiquitin interaction motif-containing protein 1 (UIMC1) or Retinoid X receptor-interacting protein 110 (RXRIP110), is a 719 amino acid protein. Acting as a transcription repressor, RAP80 interacts with GCNF, thereby blocking GCNF interaction with the corepressor N-CoR. Localized to the nucleus, RAP80 is phosphorylated upon DNA damage. RAP80 contains two nuclear localization signals and one UIM (ubiquitin-interacting motif) repeat in the N-terminus, while the C-terminus contains two zinc fingers, a third nuclear localization signal and a potential PEST sequence. RAP80 is expressed as four isoforms produced by alternative splicing and is present in thymus, testis, heart and ovary.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: UIMC1 polyclonal Antibody detects endogenous levels of UIMC1 protein.
Molecular Weight: ~ 60, 80, 120kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1; UIMC1; RAP80, RXRIP110
Immunogen: Recombinant full length Human UIMC1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: ATP-Dependent Chromatin Remodeling Complexes,