Description
WM-1119 is a potent, reversible, and competitive inhibitor of lysine acetyltransferase KAT6A ( Kd = 2 nM). Displays 1,100-fold and 250-fold selectivity over KAT5 and KAT7, respectively; causes cell cycle arrest in G1 and senescence phenotype similar to WM-8014.
WM-1119 is a potent, reversible, and competitive inhibitor of lysine acetyltransferase KAT6A ( Kd = 2 nM). Displays 1,100-fold and 250-fold selectivity over KAT5 and KAT7, respectively; causes cell cycle arrest in G1 and senescence phenotype similar to WM-8014.
Alternate Name/Synonyms: WM1119, Benzoic acid, 3-fluoro-5-(2-pyridinyl)-, 2-[(2-fluorophenyl)sulfonyl]hydrazide
Appearance: Crystalline solid
Formulation:
CAS Number: 2055397-28-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₃F₂N₃O₃S
Molecular Weight: 389.38
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >40 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent, selective inhibitor of lysine acetyltransferase KAT6A
MDL Number:
PubChem CID: 133080719
SMILES: C1=CC=C(C(=C1)F)S(=O)(=O)NNC(=O)C2=CC(=CC(=C2)C3=CC=CC=N3)F
InChi: InChI=1S/C18H13F2N3O3S/c19-14-10-12(16-6-3-4-8-21-16)9-13(11-14)18(24)22-23-27(25,26)17-7-2-1-5-15(17)20/h1-11,23H,(H,22,24)
InChi Key: QLXULUNLCRKWRD-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |