WM-1119 | B2418

WM-1119 is a potent, reversible, and competitive inhibitor of lysine acetyltransferase KAT6A ( Kd = 2 nM). Displays 1,100-fold and 250-fold selectivity over KAT5 and KAT7, respectively; causes cell cycle arrest in G1 and senescence phenotype similar to WM-8014.

WM-1119 is a potent, reversible, and competitive inhibitor of lysine acetyltransferase KAT6A ( Kd = 2 nM). Displays 1,100-fold and 250-fold selectivity over KAT5 and KAT7, respectively; causes cell cycle arrest in G1 and senescence phenotype similar to WM-8014.

B2418 | WM-1119 DataSheet

Alternate Name/Synonyms: WM1119, Benzoic acid, 3-fluoro-5-(2-pyridinyl)-, 2-[(2-fluorophenyl)sulfonyl]hydrazide

Appearance: Crystalline solid

Formulation:

CAS Number: 2055397-28-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₃F₂N₃O₃S

Molecular Weight: 389.38

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >40 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent, selective inhibitor of lysine acetyltransferase KAT6A

MDL Number:

PubChem CID: 133080719

SMILES: C1=CC=C(C(=C1)F)S(=O)(=O)NNC(=O)C2=CC(=CC(=C2)C3=CC=CC=N3)F

InChi: InChI=1S/C18H13F2N3O3S/c19-14-10-12(16-6-3-4-8-21-16)9-13(11-14)18(24)22-23-27(25,26)17-7-2-1-5-15(17)20/h1-11,23H,(H,22,24)

InChi Key: QLXULUNLCRKWRD-UHFFFAOYSA-N