Description
XL228 is a potent Tyrosine Kinase Inhibitor (TKI). It displays activity against IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases.
XL228 is a potent Tyrosine Kinase Inhibitor (TKI). It displays activity against IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases.
Alternate Name/Synonyms: 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 898280-07-4
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₃₁N₉O
Molecular Weight: 437.54
Cell-Permeable?: Yes
Purity: >98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent Tyrosine Kinase Inhibitor (TKI)
MDL Number: N/A
PubChem CID: 59757974
SMILES: CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)NC3=NNC(=C3)C4CC4)N5CCN(CC5)C
InChi: InChI=1S/C22H31N9O/c1-14(2)17-10-16(32-29-17)13-23-22-25-19(24-20-11-18(27-28-20)15-4-5-15)12-21(26-22)31-8-6-30(3)7-9-31/h10-12,14-15H,4-9,13H2,1-3H3,(H3,23,24,25,26,27,28)
InChi Key: ALKJNCZNEOTEMP-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |