XL-228 | 2632

XL228 is a potent Tyrosine Kinase Inhibitor (TKI). It displays activity against IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases.

XL228 is a potent Tyrosine Kinase Inhibitor (TKI). It displays activity against IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases.

2632 | XL-228 DataSheet

Alternate Name/Synonyms: 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 898280-07-4

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₃₁N₉O

Molecular Weight: 437.54

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent Tyrosine Kinase Inhibitor (TKI)

MDL Number: N/A

PubChem CID: 59757974

SMILES: CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)NC3=NNC(=C3)C4CC4)N5CCN(CC5)C

InChi: InChI=1S/C22H31N9O/c1-14(2)17-10-16(32-29-17)13-23-22-25-19(24-20-11-18(27-28-20)15-4-5-15)12-21(26-22)31-8-6-30(3)7-9-31/h10-12,14-15H,4-9,13H2,1-3H3,(H3,23,24,25,26,27,28)

InChi Key: ALKJNCZNEOTEMP-UHFFFAOYSA-N