ZM 336372 | 1789

Cell-permeable. A potent, selective and ATP-competitive inhibitor of c-Raf in vitro (IC₅₀ = 70 nM for inhibition of human c-Raf). Displays 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC₅₀= 2 μM).

ZM 336372 is a potent, selective and ATP-competitive inhibitor of c-Raf in vitro (IC₅₀ = 70 nM for inhibition of human c-Raf). Displays 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC₅₀= 2 μM).

1789 | ZM 336372 DataSheet

Alternate Name/Synonyms: 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 208260-29-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₃N₃O₃

Molecular Weight: 389.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A c-Raf kinase inhibitor

MDL Number: MFCD02683971

PubChem CID: 5730

SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O

InChi: InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)

InChi Key: PYEFPDQFAZNXLI-UHFFFAOYSA-N