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ULBP1 is ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines...

ULBP2, also known as NKG2D ligand 2, belongs to the MHC class I family. This protein is ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling...

UltraBrite™ black IHC chromogen (HRP) is a substrate-chromogen system designed to be used for either immunohistochemistry (IHC) or ISH when utilizing horseradish peroxidase. UltraBrite™ black IHC...

The UltraBrite™ blue IHC chromogen (AP) is a substrate-chromogen system designed to be used for either immunohistochemistry (IHC) or ISH when utilizing alkaline phosphatase. UltraBrite™ blue IHC...

The UltraBrite™ blue IHC chromogen (HRP) is a substrate-chromogen system designed to be used for either immunohistochemistry (IHC) or ISH when utilizing horseradish peroxidase. UltraBrite™ blue IHC...

The UltraBrite™ green IHC chromogen (AP) is a substrate-chromogen system designed to be used for either immunohistochemistry (IHC) or ISH when utilizing alkaline phosphatase. UltraBrite™ green IHC...

Traditional formulations for red alkaline phosphatase chromogens are unstable upon mixing. This can be problematic for use in automated slide strainers. UltraBrite™ red IHC chromogen (AP Plus) has...

The UltraBrite™ red IHC chromogen (AP) is a substrate-chromogen system designed to be used for either IHC or ISH when using alkaline phosphatase detection. The system produces a brilliant dark red...

UltraBrite™ Red IHC Chromogen is a single, highly stable, AEC chromogen/substrate working solution. When used in conjunction with immunoperoxidase detection systems, AEC produces a red colored end...

The UltraBrite™ yellow IHC chromogen (HRP) is a substrate chromogen system designed to be used for either immunohistochemistry (IHC) or ISH when utilizing horseradish peroxidase. UltraBrite™ yellow...

A1276 | UltraPolymer Donkey Anti-Goat IgG (H&L) HRP DataSheet

A1279 | UltraPolymer Donkey Anti-Sheep IgG (H&L) HRP DataSheet

UltraPolymer Goat Anti-Human IgG H&L HRP | A1278

A1275 | UltraPolymer Goat Anti-Mouse IgG (H&L) HRP DataSheet

A1274 | UltraPolymer Goat Anti-Rabbit IgG (H&L) HRP DataSheet

A1280 | UltraPolymer Goat Anti-Rabbit/Mouse IgG (H&L) HRP Cocktail DataSheet

A1277 | UltraPolymer Goat Anti-Rat IgG (H&L) HRP DataSheet

UM-164 is a potent c-Src/p38 Kinase Inhibitor with In Vivo activity against Triple-Negative Breast Cancer.UM-164 is a potent c-Src/p38 Kinase Inhibitor with In Vivo activity against Triple-Negative...

UMB-32 is an inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factors TAF1 and TAF1L. UMB-32 binds BRD4 with a Kd of 550 nM and the EC₅₀ is 724 nM in BRD4-dependent...

UMI-77 is a novel, selective, Mcl-1 SMI inhibitor. UMI-77 is selective for Mcl-1 over other members of the antiapoptotic Bcl-2 family with a Ki of 490 nM. UMI-77 acts by binding to the BH3-binding...

Umifenovir is an indole derivative with broad-spectrum antiviral activity. It inhibits virus-mediated fusion with target membrane and blocks virus entry into target cells. It shows antiviral activity...

UNBS5162 is a novel naphthalimide that suppresses the expression of CXCL chemokines. In vitro exposure of PC-3 prostate cancer cells to 1 µM UNBS5162 for five successive days is shown to decrease the...

Cell-permeable. A potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin-interacting...

UNC-2025 is a potent inhibitor of the tyrosine kinases Mer and Flt3 (IC₅₀s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC₅₀s = 14 and 17 nM, respectively) and a panel...

UNC-3866 is a potent and selective antagonist of CBX4 and CBX7 chromodomains with (Kd ≈ 100 nM). It is 6- to 63-fold selective for these chromodomains over the other CBX and CDY chromodomains...

UNC-669 is a small molecule nicotinamide derivative that acts asan antagonist of the MBT(Malignant Brain Tumor) domain, a family of methyl-lysine binding reader proteins. UNC669 displays selectivity...

UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; it binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). Selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction in a peptide pull...

UNC0224 is a selective G9a Histone Methyltransferase inhibitor. G9a methylates Histone H3 lysine 9, which is required for early embryogenesis. UNC0224 inhibits G9a with an IC₅₀ of 15 nM. It also...

UNC0321 is an inhibitor of G9a histone methyltransferase (HMTase) with picomolar potency. It is a quinazoline analogue with a Morrison Ki of 63 pM. It inhibits G9a with an IC₅₀ of 6 nM and 9 nM in...

UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SET8 (IC₅₀ = 7.3 µM; Kd = 18.3 µM). It is selective for SET8 over 15 other methyltransferases, including G9a...

UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC₅₀ = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 25 nM). It potently inhibits...

Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC₅₀ value of

UNC0642 is a potent, selective and cell-permeable inhibitor of G9a (EHMT2) and GLP (EHMT1) histone lysine methyltransferases. UNC0642 exhibits an in vitro IC₅₀ 100-fold over 13 other HMTs and...

UNC0646 is a potent and selective inhibitor of protein lysine methyltransferases G9a and GLP activities in vitro (IC₅₀s = 6 and 15 nM, respectively) ; inhibits G9a/GLP-mediated dimethylation of...

A potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC₅₀ = 2 nM). UNC1999 is >1000-fold selective for other HMTs except EZH1 (22-fold selectivity). It inhibits H3K27 methylation...

UNC-2170 is a micromolar ligand for the Methyl-lysine Binding Protein, 53BP1. UNC-2170 displays 17-fold selectivity for 53BP1 as compared to other methyl-lysine (Kme) binding proteins tested. It...

UNC2250 is an inhibitor of Mer receptor tyrosine kinase. It inhibits steady-state phosphorylation of endogenous Mer with an IC₅₀ of 9.8 nM. It blocks ligand-stimulated activation of a chimeric...

UNC2881 is a potent Mer kinase inhibitor. It inhibits steady-state Mer kinase phosphorylation with an IC₅₀ value of 22 nM. Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation...

3440 | uPAR Antibody DataSheet

3722BP | uPAR Blocking Peptide DataSheetAntibody Target: uPARAccession #: P49616Gene ID: 50692Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

UPK3A is a member of the uroplakin-3 family. Uroplakins (UP) which are transmembrane proteins are important components of the urothelium that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or...

Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.Uprosertib,...

6207 | UR144/XLR11, Synthetic Cannabinoids Antibody DataSheet

E.coli Uracil DNA Glycosylase (UDG) catalyzes the release of free uracil via hydrolysis of the N-glycosylic bond between the uracil and sugar from uracil containing single or double stranded DNA...

URB597 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH). FAAH is the enzyme that hydrolyzes anandamide (AEA) and other simple esters and amides with long unsaturated acyl...

K375 | Urea Colorimetric Assay Kit DataSheet

K376 | Urea Colorimetric Assay Kit II DataSheet

K378 | Urease Activity Assay Kit Colorimetric DataSheet

K608 | Uric Acid Colorimetric/Fluorometric Assay Kit DataSheet

K734 | Uricase Activity Assay Kit Fluorometric DataSheet

Uridine triacetate serves as an antidote for toxicities caused by 5-FU/capecitabine. Uridine triacetate delivers high concentrations of uridine, which competes with toxic 5-FU metabolites.Uridine...

URMC-099 is a brain-permeable, mixed lineage kinase (MLK) inhibitor with IC₅₀ values of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. In vitro, URMC-099 treatment...

K728 | Urokinase Activity Fluorometric Assay Kit DataSheet

5793 | Urokinase antibody DataSheet

K727 | Urokinase Inhibitor Screening Kit Fluorometric DataSheet

Urokinase is a serine protease that specifically cleaves the Arg560-Val561 bond in plasminogen to form plasmin. Urokinase Sepharose beads are designed for efficient cleavage and activation of various...

Urokinase (UK) is a serine protease, which is one of biological plasminogen activators. It is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration,...

Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC 3.4.21.73). It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic...

Urolithin A is generated by gut microflora as a natural metabolite of ellagitannins, a class of compounds found in the pomegranate and other fruits and nuts. Oral administration of urolithin A leads...

3620 | Uroplakin III Antibody DataSheet

3620BP | Uroplakin III Blocking Peptide DataSheetAntibody Target: Uroplakin III Accession #: O75631Gene ID: 7380Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

6140 | USP1 Antibody DataSheet

6134 | USP14 Antibody DataSheet

A cell-permeable, reversible and selective inhibitor of the deubiquitinating activity of human USP14 (IC₅₀ = 4-5 µM). IU1 promotes cell survival during proteotoxic stress and selectively stimulates...

6135 | USP15 Antibody DataSheet

6141 | USP2 Antibody DataSheet

6143 | USP25 Antibody DataSheet

6142 | USP3 Antibody DataSheet

6136 | USP34 Core Antibody DataSheet

6131 | USP4 Antibody DataSheet

6132 | USP5 Antibody DataSheet

USP7 Antibody | 3747

USP7/USP47 inhibitor is a dual inhibitor of ubiquitin-specific protease 7 (USP7) and USP47 (IC₅₀s = 0.42 and 1 μM, respectively). It is selective for USP7 and USP47 over USP2, USP5, USP8, USP21,...

A cell-permeable inhibitor of the ubiquitin-specific protease (IC₅₀ = 8.6 µM) and the closely related deubiquitinase (DUB) USP47. P22077 displays weak or no inhibition (EC₅₀>50 µM) towards a panel of...

6133 | USP8 Antibody DataSheet

6658BP | USP8 Blocking Peptide DataSheetAntibody Target: USP8 Accession #: P40818Gene ID: 9101Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

Uteroglobin, a member of the Secretoglobin superfamily, also known as Clara cell phospholipid-binding protein, is a multifunctional protein that can exert anti-inflammatory and anti-tumorigenic...

V-9302 is a competitive antagonist of transmembrane glutamine flux, that selectively targets the amino acid transporter ASCT2 (SLC1A5). V-9302 inhibits ASCT2-mediated glutamine uptake (IC₅₀ = 9.6 µM)...

3985 | V5-Tag Antibody DataSheet

VAL-083 | B3384Description: VAL-083 is a bifunctional alkylating agent with antitumor activity. Upon administration, VAL-083 crosses the blood brain barrier (BBB) and appears to be selective for...

Valacyclovir is a prodrug of Acyclovir (Cat.No. 2200-50, 250) with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV),...

Valbenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2). VMAT2 plays an important role in the packaging of monoamines into presynaptic vesicles. Valbenazine shows Ki values of 110...

Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID), that acts as a potent and selective inhibitor of cyclooxygenase-2 (COX-2) (IC₅₀ = 5 nM).Valdecoxib is a non-steroidal anti-inflammatory...

Valganciclovir is a L-valyl ester prodrug of ganciclovir (Cat. No. 1918), an antiviral agent used for the treatment of HIV associated retinitis and for the prevention of post-transplant...

Validamycin A is an antifungal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R. solani, due to its ability to inhibit trehalase, a trehalose-hydrolizing...

A highly selective K⁺- ionophore. It binds potassium ions (K⁺) and facilitates their transfer across lipid bilayers. Inhibits Ca²⁺-ATPase activity and promotes cell death by mitochondrial swelling...

Valnemulin is a pleuromutilin antibiotic that inhibits protein synthesis by binding to the 50S ribosomal subunit of bacteria. It is used to treat swine diseases including Brachyspira hyodysenteriae...

A cell-permeable histone deacetylase 1 (HDAC1) inhibitor (IC₅₀ = 400 µM) that exhibits anticancer, anti-inflammatory and neuroprotective properties. Recently it has been reported that Valproic acid...

Valrubicin is a cytotoxic chemotherapeutic agent that is used as an intravesical agent for BCG-refractory carcinoma in situ (CIS) of the urinary bladder.Valrubicin is a cytotoxic chemotherapeutic...

Cell-permeable. A high affinity angiotensin I receptor antagonist (Ki = 2.38 nM). Clinically useful antihypertensive agent. Active in vivo. Also, a recent study has shown that Valsartan lowers brain...

E4605 | Vancomycin Elisa Kit DataSheet

Vancomycin is a glycopeptide antibiotic identified for its utility in the treatment of gram-positive bacteria, including penicillin-resistant staphylococci. It acts by binding to bacterial cell wall...

A potent inhibitor of kinase insert domain-containing receptor [KDR/vascular endothelial growth factor receptor (VEGFR) 2] tyrosine kinase activity (IC₅₀ = 40 nM). This compound also inhibits...

VAP-1 is a type II membrane cell adhesion protein belonging to the copper/topaquinone oxidase family. It is primarily expressed on the high endothelial venules of peripheral lymph nodes and on...

Varlitinib is a potent inhibitor of the epidermal growth factor receptor (EGFR) family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and...

3718 | VASP Antibody DataSheet

3718BP | VASP Blocking Peptide DataSheetAntibody Target: VASP Accession #: P50552Gene ID: 7408Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) VASP peptide in...

K4917 | Vaspin human Serum Elisa Kit DataSheet

Vaspin (visceral adipose-specific SERPIN), a newly identified adipokine, is a member of serine protease inhibitor family. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A...

Cell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. At higher...