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WAY-362450 is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist with an EC50 of 4 nM.WAY-362450 is a highly potent, selective, and orally active farnesoid X receptor...

WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold)...

WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM). It inhibits the catalytic activity of MLL core complex in in vitro experiments with IC₅₀ of 39 µM. WDR5 is a...

6846 | WDR5 polyclonal antibody DataSheet

Wedelolactone is a natural coumestan that irreversibly inhibits IKK in NF-κB signaling pathway. IKK phosphorylates the IκBα protein, which results in the degradation and dissociation of IκBα from...

3120 | Wee1 Antibody DataSheet

3120BP | Wee1 Blocking Peptide DataSheetAntibody Target: Wee1 Accession #: P47810Gene ID: 22390Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

WEHI-539 | B1818

WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC₅₀ of 2 nM and 6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.WH-4-023 is a potent and selective dual...

Cell-permeable. Selectively inhibits the tyrosine kinase activity of Jak3 with an IC₅₀ value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases. Also...

WHI-P154 is a potent JAK3 inhibitor (IC₅₀ of 1.8 μM). It displays no activity against JAK1 or JAK2. Also inhibits EGFR, Src, Abl, VEGFR and MAPK, and prevents Stat3, but not Stat5 phosphorylation...

WHI-P180 is a multi-kinase inhibitor. It inhibits human proto-oncogene receptor tyrosine kinase RET (Rearranged during Transfection) and kinase insert domain receptor (KDR) with IC₅₀ values of 4.5 nM...

Buffer for diluting Antibodies1270 | white plates DataSheetSort Name: Antibody Dilution bufferLabel Name: N/ATaglines: Buffer to effectively dilute a concentrated antibody solutionProduct Highlights:...

K528 | Whole Blood DNA Isolation Kit DataSheet

Whole Blood Pcr Mix | M1143

Wide range 1 kb DNA LadderM1191 | Wide range 1 kb DNA Ladder DataSheetSort Name: Wide range 1 kb DNA LadderLabel Name: Wide range 1 kb DNA LadderTaglines: Wide range 1 kb DNA LadderProduct...

Wide range 100 bp DNA LadderM1192 | Wide range 100 bp DNA Ladder DataSheetSort Name: Wide range 100 bp DNA LadderLabel Name: Wide range 100 bp DNA LadderTaglines: Wide range 100 bp DNA LadderProduct...

WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM); inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM).WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50...

(+)-WIN 55,212-2 (mesylate) is a potent aminoalkyl indole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. It shows...

WISP-1 is a member of the CCN family of secreted cysteine rich regulatory proteins. It is expressed in the heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. WISP-1 is a...

WISP-3 is a member of the CCN family of secreted cysteine rich regulatory proteins. It is predominantly expressed in the adult kidney, testis and fetal kidney and weaker expression in placenta,...

Withaferin A is a steroid lactone that displays potent anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo...

WM-1119 is a potent, reversible, and competitive inhibitor of lysine acetyltransferase KAT6A ( Kd = 2 nM). Displays 1,100-fold and 250-fold selectivity over KAT5 and KAT7, respectively; causes cell...

Cell-permeable. A potent Wnt signaling pathway inhibitor (IC₅₀ =

3571 | Anti-Wnt-1 Antibody DataSheet

3571BP | Wnt-1 Blocking Peptide DataSheetAntibody Target: Wnt-1 Accession #: P04628Gene ID: 7471Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade...

6671 | Wnt-2 Antibody DataSheet

3572RBP | Wnt-2 Blocking Peptide DataSheetAntibody Target: Wnt-2 Accession #: P09544Gene ID: 7472Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

This protein belongs to the Wnt family of proteins. The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway. Wnt gene...

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes,...

3574R | Wnt-4 Antibody DataSheet

3574BP | Wnt-4 Blocking Peptide DataSheetAntibody Target: Wnt-4 Accession #: BAC23080Gene ID: 54361Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

3570 | Wnt-6 Antibody DataSheet

3570BP | Wnt-6 Blocking Peptide DataSheetAntibody Target: Wnt-6 Accession #: NP_033552.2Gene ID: 22420Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

WNT7A is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several...

Wogonin, isolated from roots of Scutellaria baicalensis Georgi, displays a variety of biological and pharmacological properties, including antioxidant, anti-inflammatory, and anticancer activities...

Wogonoside is a flavonoid with antioxidant, anti-cancer and anti-angiogenic activity. Wogonoside inhibits the growth of U937 and HL-60 cells cells. It arrests the cell cycle at the G0/G1 phase and...

Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC₅₀ = 2-4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC₅₀ = 5.8 nM)...

Cell-permeable. WP1130 acts as a partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein...

A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and...

The Wright-Giemsa Solution is intended for differential staining of blood smears, bone marrow and blood parasites (Cat# K1439). Use in conjunction with Phosphate Buffer Solution pH 6.8.M1438 |...

K1438 | Wright-Giemsa Stain Kit DataSheet

WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM (induced R7T1 proliferation). More recently, WS3 has been found to mediate proliferation of primary retinal pigment...

WS6 is a novel Inducer of β cell proliferation. Inthe RIP-DTA mouse model of β cell ablation, WS6 normalizes blood glucose and induces concomitant increases in β cell proliferation and β cell number...

A water-soluble tetrazolium reagent that serves as a sensitive chromogenic indicator for NADH. It is reduced by NADH at neutral pHs in the presence of 1-methoxy PMS to produce the corresponding...

WST-3 is a highly sensitive tetrazolium reagent that produces a water-soluble, colored formazan dye with reducing agents such as NADH.WST-3 is a highly sensitive tetrazolium reagent that produces a...

WST-8 is a next generation tetrazolium reagent that serves as a sensitive chromogenic indicator for NADH. It is reduced by NADH at neutral pHs in the presence of 1-methoxy PMS to produce the...

K543 | WST-NR-CV Combined Cytotoxicity Assay Kit DataSheet

WT-161 is a potent, selective, and bioavailable HDAC6 (histone deacetylase-6) inhibitor (IC₅₀ 0.40 nM). It is selective for HDAC6 over HDAC3 (IC₅₀ = 51.61 nM) and induces α-tubulin acetylation, an...

Cell-permeable. A selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively.WY-14643 is a selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at...

WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2.WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50...

WYE-687 is an ATP-competitive and selective inhibitor of mTOR with an IC50 value of 7 nM.WYE-687 is an ATP-competitive and selective inhibitor of mTOR with an IC50 value of 7 nM.B1730 | WYE-687...

WZ-3146 is a mutant selective EGFR inhibitor with IC₅₀s of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750, EGFRE746_A750/T790M and EGFR, respectively.WZ-3146 is a mutant...

WZ-8040 is a potent EGFR inhibitor that suppresses the growth of EGFR-T790M (a mutation of the gatekeeper T790 residue) containing cell lines and inhibits EGFR phosphorylation.WZ-8040 is a potent...

A third generation EGFR inhibitor. Selectively inhibits mutant EGFR T790M. Inhibits EGFR phosphorylation and induces siginificant tumor regressionin murine model of EGFR T790M. WZ4002 can overcome...

WZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibits cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC₅₀ of approximately 10 μM.WZB117 is an...

X-GAL is a useful chromogenic substrate for β-galactosidase that produces a rich blue color that can easily be detected visually over background. X-GAL is used to indicate whether a cell expresses...

3696 | XAF-1 Antibody DataSheet

3696BP | XAF-1 Blocking Peptide DataSheetAntibody Target: XAF-1 Accession #: CAA68030Gene ID: 54739Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

K710 | Xanthine Oxidase Activity Colorimetric/Fluorometric Assay Kit DataSheet

K685 | Xanthine/Hypoxanthine Colorimetric/Fluorometric Assay Kit DataSheet

Cell-permeable. A bioactive flavonoid antioxidant found in the flowering hops plant. Binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome...

A Tankyrase (TNKS) inhibitor (IC₅₀ = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the...

XEN445 is a potent and selective endothelial lipase (EL) inhibitor. It displays good ADME and PK properties and shows in vivo efficacy in raising plasma HDL cholesterol concentration in mice.XEN445...

Xestospongin C is a marine natural product isolated from Pacific basin sponges; it antagonizes the calcium-releasing action of inositol-1,4,5-trisphosphate (IP3) at the receptor level. Xestospongin C...

3183 | XIAP Antibody DataSheet

3183BP | XIAP Blocking Peptide DataSheetAntibody Target: XIAP Accession #: AAH32729Gene ID: 331Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

XL-147 is an ATP-competitive, highly selective, and reversible pan-class I phosphoinositide 3-kinase (PI3K) inhibitor. It inhibits PI3K p110α, -β, -γ, and -δ isoforms, with IC₅₀ values of 48, 617,...

XL-147 | B3352Description: XL-147 is a potent and reversible Class 1 PI3-kinase family inhibitor with potential antineoplastic activity. Inactivation of PI3K has been shown to inhibit growth and...

XL228 is a potent Tyrosine Kinase Inhibitor (TKI). It displays activity against IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases.XL228 is a potent Tyrosine Kinase Inhibitor (TKI). It...

XL-647 is an orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. It binds to and inhibits several receptor tyrosine kinases that play...

XL019 is a potent, highly selective and reversible JAK2 inhibitor (IC₅₀ = 2.2 nM). Inhibits JAK1 (IC₅₀ = 134.3 nM), JAK3 (IC50 = 214.2 nM) and TYK2 (IC₅₀ = 348.3 nM) at higher concentrations. XL019...

XL388 is a potent and selective inhibitor of mTOR with IC50 value of 9.9 nM.XL388 is a potent and selective inhibitor of mTOR with IC50 value of 9.9 nM.B1733 | XL388 DataSheetAlternate Name/Synonyms:...

XL765 is a dual inhibitor of mTOR/PI3K with potential anticancer activities. XL765 inhibits both PI3 kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in...

XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. XL888 specifically binds to Hsp90, inhibiting its...

3757 | XLF Antibody DataSheet

XMD17-109 is a novel, specific ERK-5 inhibitor, which inhibits the ERK5-mediated AP1 transcriptional activity at 30 μM, and has an EC50 of 4.2 μM.XMD17-109 is a novel, specific ERK-5 inhibitor, which...

XMD8-87 is a potent Ack1/TNK2 inhibitor (IC₅₀ = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations respectively). XMD8-87 potently inhibits phosphorylation of...

XMD8-92 is a highly selective ERK5/BMK1 inhibitor with dissociation constant (Kd) value of 80 nM.XMD8-92 is a highly selective ERK5/BMK1 inhibitor with dissociation constant (Kd) value of 80 nM.B1684...

XMU-MP-1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC₅₀ values are 38.1 and 71.1 nM for MST2 and MST1, respectively). It is selective for MST1...

XRK3F2 is an inhibitor of the p62-ZZ domain (Sequestosome 1) that inhibits MM cell growth and BMSC growth enhancement of human MM cells. XRK3F2 induces dramatic cortical bone formation that is...

XTT Cell Viability Assay Kit (Colorimetric) | K2108-100Description: ’s XTT Cell Viability Assay Kit is a colorimetric assay for studying cell proliferation and cell cytotoxicity. The assay is based...

XTT sodium is a useful dye to measure cell proliferation, cytotoxicity, and apoptosis through colorimetric assay. XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a...

XY1 is an inactive control of SGC707. SGC707 is a potent, selective and allosteric inhibitor of Protein arginine methyltransferase3 (PRMT3) with an IC₅₀ of 31 nM. It inhibits the methylation of...

Xylitol is a sugar alcohol derived from xylose by reduction of the carbonyl group. It is used as a food additive and sugar substitute. It is found in many fruits and vegetables. It is added to some...

Selective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and >250 µM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase, respectively...

Y-320 is an immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.Y-320 is an immunomodulator. Y-320 inhibits IL-17 production by CD4 T...

Y15 is a selective focal adhesion kinase (FAK) inhibitor preventing FAK autophosphorylation at IC₅₀ of 1 μM. It does not have any significant activity against a range of other kinases like EGFR,...

3815 | YAP1 Antibody DataSheet

3815BP | YAP1 Blocking Peptide DataSheetAntibody Target: YAP1 Accession #: P46937Gene ID: 10413Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

Cell-permeable. A nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator (EC₅₀ = 18 µM). Induces concentration-dependent increase in cGMP levels in cultured...

’s Yeast Extract is prepared from autolyzed yeast. It is used in preparing microbiological culture media. Yeast extract is the water soluble portion of autolyzed yeast. The autolysis is carefully...

K1414 | Yeast Genomic DNA Kit DataSheet

Proteases (also called Proteolytic Enzymes, Peptidases, or Proteinases) are enzymes that hydrolyze the amide bonds within proteins or peptides. Most proteases act in a specific manner, hydrolyzing...

Mitochondria are the power house of the cells as they generate most of the supply of energy in the form of adenosine tri-phosphate (ATP). Mitochondria are double membrane organelles comprising of an...

K259 | Yeast Mitochondria Isolation Kit DataSheet

Yeast Mitochondria Pichia pastoris | 1111

K289 | Yeast Nuclei Isolation Kit DataSheet

K1418 | Yeast RNA Mini Kit DataSheet